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Brigitte M Frey Selected Research

11-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)

1/2014Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11β-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines.
2/2009Prematurity is related to high placental cortisol in preeclampsia.
6/2008Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients.
11/2007Identification of polymorphisms in the human 11beta-hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity.
1/2006Analbuminemic Nagase rats: blood pressure response to dietary salt challenge.
12/2005Extracellular ATP determines 11beta-hydroxysteroid dehydrogenase type 2 activity via purinergic receptors.
7/2004Glucocorticoid-mediated mineralocorticoid receptor activation and hypertension.
2/2004The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist.
12/2003A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity.
9/2003Angiotensin II regulates 11beta-hydroxysteroid dehydrogenase type 2 via AT2 receptors.
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Brigitte M Frey Research Topics

Disease

13Hypertension (High Blood Pressure)
10/2014 - 01/2002
7Pre-Eclampsia (Preeclampsia)
11/2013 - 09/2003
4Prostatic Neoplasms (Prostate Cancer)
04/2018 - 06/2011
3Neoplasms (Cancer)
06/2011 - 02/2004
3Inflammation (Inflammations)
03/2010 - 12/2005
3Hypoxia (Hypoxemia)
10/2005 - 05/2003
3Edema (Dropsy)
08/2005 - 01/2005
3Nephrotic Syndrome (Syndrome, Nephrotic)
01/2005 - 05/2002
2Essential Hypertension
01/2014 - 11/2007
2Vascular Calcification
06/2011 - 12/2008
2Ischemia
12/2005 - 05/2003
2Liver Cirrhosis (Hepatic Cirrhosis)
09/2005 - 07/2004
2Renal Insufficiency (Renal Failure)
10/2004 - 05/2002
2Chronic Kidney Failure (Chronic Renal Failure)
10/2004 - 04/2002
1Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
04/2018
1Cortisone reductase deficiency
11/2015
1Breast Neoplasms (Breast Cancer)
03/2015
1Congenital Heart Defects (Congenital Heart Defect)
03/2014
1Critical Illness (Critically Ill)
03/2014
1Colonic Neoplasms (Colon Cancer)
01/2014
1Microvascular Rarefaction
05/2013
1Body Weight (Weight, Body)
01/2011
1Acute Kidney Injury (Acute Renal Failure)
03/2010
1Hyperkalemia
10/2009
1Bicuspid Aortic Valve Disease
09/2009
1Aneurysm (Aneurysms)
09/2009
1Aortic Aneurysm (Aneurysm, Aortic)
09/2009
1Marfan Syndrome (Marfan's Syndrome)
09/2009
1Birth Weight (Birth Weights)
02/2009
1Fetal Growth Retardation (Intrauterine Growth Retardation)
02/2009
1Obesity
02/2009
1Calciphylaxis
12/2008
1Chronic Renal Insufficiency
12/2008

Drug/Important Bio-Agent (IBA)

1111-beta-Hydroxysteroid Dehydrogenase Type 2 (11 beta-Hydroxysteroid Dehydrogenase Type 2)IBA
01/2014 - 05/2003
9EnzymesIBA
04/2018 - 05/2003
9SodiumIBA
01/2014 - 01/2002
8Hydrocortisone (Cortisol)FDA LinkGeneric
01/2011 - 01/2002
7GlucocorticoidsIBA
10/2013 - 05/2002
6AldosteroneIBA
11/2013 - 05/2002
5SaltsIBA
10/2014 - 10/2004
4MineralocorticoidsIBA
01/2014 - 05/2003
4Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
06/2008 - 12/2003
3SteroidsIBA
04/2018 - 03/2014
3Oxidoreductases (Dehydrogenase)IBA
11/2015 - 12/2004
311-beta-Hydroxysteroid Dehydrogenase Type 1IBA
02/2009 - 12/2003
3PotassiumIBA
07/2004 - 01/2002
2Androgen Receptors (Androgen Receptor)IBA
03/2015 - 06/2011
2LigandsIBA
03/2015 - 10/2005
2AndrogensIBA
03/2014 - 12/2011
2IsoenzymesIBA
01/2014 - 09/2003
2Lactic Acid (Lactate)FDA LinkGeneric
01/2014 - 10/2005
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2013 - 10/2005
2Prostate-Specific Antigen (Semenogelase)IBA
12/2011 - 06/2011
2sodium thiosulfateFDA Link
06/2011 - 12/2008
2Spironolactone (Aldactone)FDA LinkGeneric
01/2011 - 07/2004
2Proteins (Proteins, Gene)FDA Link
03/2010 - 05/2003
2Puromycin AminonucleosideIBA
01/2005 - 05/2002
2CortisoneFDA Link
12/2004 - 01/2002
2Angiotensin IIIBA
07/2004 - 09/2003
211-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA
05/2003 - 05/2002
1Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
04/2018
1Pharmaceutical PreparationsIBA
04/2018
1abirateroneIBA
04/2018
1Cytostatic AgentsIBA
03/2015
1MicroRNAs (MicroRNA)IBA
10/2014
1Estrogens (Estrogen)FDA Link
03/2014
1ProgesteroneFDA LinkGeneric
03/2014
1Insulin (Novolin)FDA Link
01/2014
1CCAAT-Enhancer-Binding ProteinsIBA
01/2014
1Tyrosine (L-Tyrosine)FDA Link
05/2013
1Androgen Antagonists (Antiandrogens)IBA
12/2011
1Gentian Violet (Violet, Crystal)FDA Link
12/2011
1(3- dimyristyloxypropyl)(dimethyl)(hydroxyethyl)ammoniumIBA
06/2011
1Diphtheria ToxinIBA
06/2011
1LipidsIBA
06/2011
1ImmunosorbentsIBA
03/2010
1Carrier Proteins (Binding Protein)IBA
03/2010
1Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
03/2010
1UromodulinIBA
03/2010
1AlbuminsIBA
03/2010
1Leucine (L-Leucine)FDA Link
03/2010
1AdrenomedullinIBA
03/2010
1ZincIBA
03/2010
1Glycoproteins (Glycoprotein)IBA
03/2010
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
03/2010
1ProteomeIBA
03/2010
1Retinol-Binding Proteins (Retinoid Binding Proteins)IBA
03/2010
1Immunoglobulins (Immunoglobulin)IBA
03/2010
1Serine Proteases (Serine Protease)IBA
03/2010
1FilaminsIBA
09/2009
1microfibrillar proteinIBA
09/2009
1CalponinsIBA
09/2009
1CalpainIBA
09/2009
1SpectrinIBA
09/2009
1VinculinIBA
09/2009

Therapy/Procedure

3Therapeutics
04/2018 - 06/2011
2Renal Dialysis (Hemodialysis)
10/2009 - 01/2002
1Castration
12/2011
1Extracorporeal Circulation
03/2010
1Cardiopulmonary Bypass (Heart-Lung Bypass)
03/2010